Ultrastructural Changes in Chondrocyte Mitochondria Associated with Strontium-Induced Rickets

Ultrastructural changes associated with dexamethasone-induced ocular hypertension in mice.

PURPOSE To determine whether dexamethasone (DEX)-induced ocular hypertension (OHT) in mice mimics the hallmarks of steroid-induced glaucoma (SIG) in humans, including reduced conventional outflow facility (C), increased extracellular matrix (ECM), and myofibroblasts within the outflow pathway. METHODS Osmotic mini-pumps were implanted subcutaneously into C57BL/6J mice for systemic delivery of...

Rickets and soil strontium.

The subjects of this study were children aged 6-60 months living in villages in the Ulas Health Region, Sivas. The villages were divided into two groups according to the amount of strontium in the soil: region 1, > 350 ppm, 650 children; region 2, < 350 ppm, 1596 children. Overall, the prevalence of one or more clinical signs of rickets was 22.9%. The prevalence in region 1 was 31.5% and that i...

Ultrastructural and biochemical changes associated with pyrrolizidine-induced hepatic megalocytosis.

Ion-induced Ultrastructural Transformations in Isolated Mitochondria

The energized uptake of low levels of Ca(2+) in the presence and absence of phosphate by isolated rat liver mitochondria, and the perturbation effected by this activity on ultrastructural and metabolic parameters of mitochondria have been investigated. In the presence of phosphate, low levels of Ca(2+) are taken up by mitochondria and result in various degrees of ultrastructural expansion of th...

Ultrastructural changes of endothelium associated with thrombocytopenia.

In a study of the relationship between thrombocytopenia and increased vascular fragility, changes in the endothelium of capillaries and postcapillary venules of the tongue were examined by electron microscopy. Adult male albino rabbits (4 kg) were maintained thrombocytopenic (platelets less than 20,000/cu mm) up to 24 hr by one to three injections of guinea pig antirabbit platelet serum. Within...